2025 Tabular Data https://fordatis.fraunhofer.de/handle/fordatis/434
http://dx.doi.org/10.24406/fordatis/388

Under pressure: Mimicking bedsores with full-thickness skin equivalents in vitro

Unter Druck: Nachahmung von Druckgeschwüren mit in vitro Vollhautmodellen

Kiesewetter, Lisa (Fraunhofer-Institut für Silicatforschung ISC, Translationszentrum für Regenerative Therapien TLZ-RT); Wußmann, Maximiliane (Fraunhofer-Institut für Silicatforschung ISC, Translationszentrum für Regenerative Therapien TLZ-RT); Groeber-Becker, Florian (Fraunhofer-Institut für Silicatforschung ISC, Translationszentrum für Regenerative Therapien TLZ-RT & University Hospital Duesseldorf, Department Ophthalmology)

ISC Fraunhofer-Institut für Silicatforschung
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FileDescriptionSizeFormat 
Figure2_Lactate.csvLactate production in mM for full-thickness skin equivalents of three donors A, B, C and different durations of pressure treatment. Data underlying Figure 2.787 BCSVDownload/Open
Figure2_LDH.csvLactate deyhrodgenase release in U/l for full-thickness skin equivalents of three donors A, B, C and different durations of pressure treatment. Data underlying Figure 2.387 BCSVDownload/Open
Figure2_RelativeROS.csvRelative reactive oxygen species synthesis in % of untreated models, for full-thickness skin equivalents of three donors A, B, C and different durations of pressure treatment. Data underlying Figure 2.685 BCSVDownload/Open
Figure3_DermalThickness.csvDermal thicknesses in µm resulting histological pictures of full-thickness skin equivalents of three donors A, B, C and different durations of pressure treatment. Data underlying Figure 3.537 BCSVDownload/Open
Figure3_EpidermalThickness.csvEpidermal thicknesses in µm resulting histological pictures of full-thickness skin equivalents of three donors A, B, C and different durations of pressure treatment. Data underlying Figure 3.480 BCSVDownload/Open
Figure6_LDH.csvLactate deyhrodgenase release in U/l for full-thickness skin equivalents of three donors A, B, C and different durations of pressure treatment and 20h reperfusion. Data underlying Figure 6.426 BCSVDownload/Open
FIgure6_RelativeROS.csvRelative reactive oxygen species synthesis in % of untreated models, for full-thickness skin equivalents of three donors A, B, C and different durations of pressure treatment and 20h reperfusion. Data underlying Figure 6.538 BCSVDownload/Open
Figure2_Glucose.csvGlucose consumption in mM for full-thickness skin equivalents of three donors A, B, C and different durations of pressure treatment. Data underlying Figure 2.774 BCSVDownload/Open
Figure5_PixelDensitiyofProteinLevels.csvRelative change of pixel density of protein levels after 4-hour compression resulting chemiluminescent images of humane cytokine proteome arrays, normalized to a positive reference spot (set to 100 %) for three donors A, B, C. Skin models with 4h compression and 20h reperfusion set in relation to untreated skin models.4,04 kBCSVDownload/Open

Abstract

Collected research data (measurements) for in vitro full-thickness skin models from three biological donors A, B, C, which were injured with pressure-induced wounds employing a magnet. The data tables list the results of metabolic analyses (glucose, lactate), viability markers (lactate dehydrogenase), as well as reactive oxygen species (ROS) and analysis of protein levels over the various durations of the pressure treatment and subsequent reperfusion phase, which support the figures in the publication.

Technical Information

csv data tables (to be read with Microsoft Excel or any text editor)
Classification
570 Biowissenschaften; Biologie
600 Technik, Technologie
Keywords
Tissue Engineering
Biomedicine
in vitro
Test system
full-thickness skin equivalent
bedsore
Dekubitus
Hautmodell
Funder
Bundesministerium für Wirtschaft und Klimaschutz BMWK (Deutschland)
Fraunhofer Group
Gesundheit
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